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The study did not apply a modern multi-dose response-surface, Bliss independence, or Loewe additivity analysis, so the term synergistic should be understood as reflecting the original authors terminology under their specific experimental design

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Stop and reassess Stop the protocol and seek qualified medical care if pronounced symptoms appear: significant swelling, ongoing dizziness, rapid heart rate, shortness of breath, or marked fatigue

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Cunha KSG, Caruso AC, de Faria PAS, da Silva LE, Pires ARC, Geller M, et al