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The natural form of folate, 5-methylTHF (methylfolate), offers several advantages compared to folic acid: it does not mask B12 deficiency, it is already a biologically active form, it does not cause unmetabolized folic acid in blood, and it is absorbed and utilized at least as well as folic acid

Possible clinical applications are women with central obesity, HIV-associated lipodystrophy, or metabolic syndrome in which visceral fat negatively affects reproductive outcomes

Patients should be aware that purchasing either of these peptides from unregulated online sources carries significant legal and health risks

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For severe deficiency, patients get 1,000 mcg daily for the first week