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Circulation 133 , 24592502 (2016)
Compounded semaglutide is the lower-cost option
While earlier work focused on direct action on pancreatic beta cells, more recent work has described additional neural actions including a satiety effect
affected people may use fewer (or no) substances and not agonize over it
)
Moreover, the pharmacokinetics of injected GLP-1 RAs can be a limitation, necessitating frequent dosing schedules that may deter long-term use
Some users combine with non-incretin compounds, though this should be approached cautiously
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