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Tomatsu et al., 2007
This is more pronounced when the dose of the GLP-1 is being adjusted or produces side effects like vomiting
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The downstream signaling events increase nuclear translocation of NF-B, further promoting the production of various proinflammatory and profibrogenic cytokines, such as TNF, IL-1, CCL5, and TGF, which subsequently induce hepatocyte lipid accumulation and apoptosis and HSC activation
Emotional eating, sleep deprivation (which disrupts hunger hormones), and the stress of new parenthood all contribute to weight gain that medications alone do not solve
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