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Indeed, recent data suggest that a chronic elevation of homocysteine level might indirectly reduce methylation of DNA, RNA, proteins, and phospholipids through a concomitant increase in SAH level secondary to homocysteine-mediated reversal of the SAH hydrolase reaction (Yi et al, 2000)

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In vitro effects of cadmium and nickel on glutathione, lipid peroxidation and [PMID: 20650202] Laboratory literature summary: In vitro effects of cadmium and nickel on glutathione, lipid peroxidation and glutathione S-transferase in research subjects kidney