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They are often sold through questionable channels, sometimes labelled as research compounds

These blood tests can help determine if youre low on B12 (6)

The overall discontinuation rate was 4.3% to 7.1% (Jastreboff et al., NEJM 2022)

The same applies if your elevated B12 is accompanied by abnormal results on other labs (liver enzymes, kidney markers, CBC), or by symptoms like unexplained weight loss, persistent fatigue, abdominal pain, or easy bruising

But they depend entirely on you remembering them daily, and without testing, you have no way to confirm they are working

Reported concerns may include headache, nausea, injection-site irritation, fatigue, or unpredictable responses depending on product quality and route of administration