O., Jr, Farese, J
Conflict of interest Flynn McGuire, Riley Martinez, Annika Lenz, Lee Skinner, and Dan Cushman declare that they have no conflict of interest
Neither point is a claim that it works in humans
Risk and Handling Precautions Risk Tier: MODERATE This rating reflects both peptides' bioactive activity at angiogenic and cytoskeletal signaling pathways in preclinical models, the absence of established human safety profiles for either compound, and the additional handling considerations specific to intranasal formulations
PT-141 (bremelanotide, brand name Vyleesi) is approved for hypoactive sexual desire disorder in premenopausal women
Given the strong link between sleep function and depressive states, this peptide, which appears to influence the sleep cycle, could also be of research interest in the context of depression onset