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Effectiveness and safety of daily oral semaglutide in people with type 2 diabetes mellitus switching from sulfonylureas

In the COR clinical trial program, patients taking Contrave alongside diet and exercise modifications lost an average of approximately 56% of their body weight over 56 weeks, compared with placebo

Genetic variation in GLP-1 receptor sensitivity (rs6923761) and GIP receptor variants (rs1800437) may explain why some patients achieve robust weight loss with lower doses while others require higher doses or experience unexpected tolerability challenges

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