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Exposure to light, particularly UV light, triggers photodegradation that breaks down the peptide structure

Research also indicates that people who take these medications are at increased risk of gastrointestinal events, such as pancreatitis, bowel obstruction, or gastroparesis

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Results were that incidence of biliary disease, i.e., conditions that effect the gallbladder/bile ducts, (per 1,000 person-years) was 11.7 for semaglutide, 18.6 for liraglutide (another GLP-1 agonist), and 12.6 for bupropion-naltrexone and 4.6, 7.9 and 1.0, respectively, for pancreatitis

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