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Introduction Amodiaquine is a potent anti-malaria drug, however, rare but life-threatening idiosyncratic hepatotoxicity (1/15,500 patients) and agranulocytosis (1/2000 patients) have restricted its therapeutic use (Olliaro and Mussano, 2003
Metabolism of acetaminophen by CYP2E1 produces a highly HIGHLY REACTIVE AND TOXIC metabolite called N-acetyl-p-benzoquinone (NAPQI)
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Figure 1 3.2 Lipid peroxidation and oxidative stress Ferroptosis is ultimately driven by ROS-mediated lipid peroxidation
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