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Moreover, systemic activation of PPAR increases food intake and body weight in rodents 8 and neuron-specific deletion of PPAR decreases body weight and food intake in mice fed a high-fat diet 9

Selenium-containing drugs are expected to lead to important advances in novel cancer therapeutics, due the involvement of GPX4 in the elimination of lipid peroxides and in ferroptosis prevention

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12 13 Therapeutic Potential : In sleep medicine, modulating orexin pathways is a promising strategy for addressing conditions such as insomnia and excessive wakefulness