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However, the absence of a direct drug-drug interaction does not mean that combining these medications is without considerations

These conditions are all closely related to hypoxia-induced endothelial cell senescence

Contrave (Naltrexone/Bupropion) Contrave is a non-injectable prescription medication that combines two drugs: naltrexone (commonly used for addiction treatment) and bupropion (often prescribed for depression or smoking cessation)

doi:10.1186/s13104-015-1437-9

Can protect heart health

Its stage table lists insulin or other agents as preferred through the first trimester and says providers typically continue those alternatives into the second and third trimesters