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In this context it is known that SOD, CAT and GPX are regulated at transcriptional levels by cellular redox status, through a mechanism that involves the interaction between the antioxidant responsive elements (ARE) and the nuclear factor-erythroid 2-related factor 2 (Nfr2) [83, 84] (Fig

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This subtype may also be tied into pelvic floor dysfunction or have a hormonal contribution thus the recommendation of a vaginal estrogen