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Humane endpoints: Animals were euthanized if tumor volume exceeded 2000 mm, if tumors reached 10% of body weight, if body weight loss exceeded 2025%, or if signs of cachexia or severe distress were observed

If gastrointestinal side effects such as nausea or early satiety are severe, the FDA label recommends delaying dose escalation or temporarily maintaining the current dose until symptoms improve

Just like a new relationship, you wouldnt want emotional baggage from the previous one, would you

The mental side of performance matters too

This is to say that, although training must become harder over time so as to create overload, training beyond what one can recover from is detrimental to performance, and will increase the likelihood of injury

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