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The latter in turn is responsible for an increased melanin count in the body
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More recently, two dual-acting GLP-1/GIP agonists have been approved, Mounjaro (tirzepatide) for type 2 diabetes and Zepbound (tirzepatide) for chronic weight management
These findings have also been described for MDD, e.g., in a large meta-analysis by Bot and Milaneschi et al., which found an association between depression risk and different lipid classes [14] and in several other studies, as reviewed in detail by Guerreiro Costa et al
Skipping titration increases the likelihood of severe nausea, vomiting, prolonged diarrhea , and potentially dangerous dehydration
Diarrhoea was among the most frequently reported adverse effects in the Phase 2 NEJM trial, occurring in a dose-dependent pattern and most commonly during dose escalation
