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Therefore, an approach using multiple donors, donor-matched tissue and pooled-donor samples in ALI exposures may support the understanding of inter-individual variability within in vitro assays (Moreau et al., 2022) by ideally using a broad set of different inhaled materials covering a diversity regarding chemical structures
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Coskun T, Urva S, Roell WC, Qu H, Loghin C, Moyers JS, O'Farrell LS, Briere DA, Sloop KW, Thomas MK, Pirro V, Wainscott DB, Willard FS, Abernathy M, Morford L, Du Y, Benson C, Gimeno RE, Haupt A, Milicevic Z
Dose escalation can influence timing because gastrointestinal symptoms may flare around changes
They studied 6,070 patients aged 24 and older, all with obesity (BMI 30) and type 2 diabetes diagnosed after age 21, treated between 2008 and 2021
Medical organizations including the American College of Obstetricians and Gynecologists acknowledge that some GLP-1 drugs may be compatible with lactation on a case-by-case basis, but semaglutide specifically lacks sufficient human data for confident reassurance
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