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Dioxin, like any endocrine-disrupting chemical, can induce insulin resistance by its direct effect on the -cell of the pancreas, in addition to its indirect effect by inducing adipogenesis, stimulating lipid storage, and altering the production of adipocytokines via activation of peroxisome proliferator-activated receptor-alpha (PPAR) (Street et al

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Insulin signaling pathway and related molecules: Role in neurodegeneration and Alzheimers disease

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The expression of CBS and CSE seems to be cancer type-related often dependent on the organ and the genetic background