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As GLP-1 therapies expand beyond diabetes and obesity, understanding their anti-inflammatory mechanisms may unlock new therapeutic uses
The Phase 2 dose-finding trial (N=338), published in the New England Journal of Medicine in 2023 (DOI: 10.1056/NEJMoa2301972), randomized participants with obesity (BMI 30-50) to retatrutide at doses ranging from 0.5mg to 12mg weekly or placebo over 48 weeks
That all may change soon, at least for BPC-157, KPV, TB-500, MOTS-c, Epitalon, and Semax
Such complications could turn deadly
Combination formulations that include GLP-1 medications with other weight management or diabetes medications in a single delivery system are also being explored
It also lowers the risk of major cardiovascular events such as stroke, heart attack, or death in adults with type 2 diabetes who also have heart disease, and lowers the risk of worsening kidney disease, kidney failure (end-stage kidney disease), and death due to cardiovascular disease in adults with type 2 diabetes who also have chronic kidney disease
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