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While Zepbound causes thyroid C-cell tumors in rats, its unknown whether it causes these tumors in humans, so it should not be used by patients with a personal or family history of medullary thyroid cancer or with multiple endocrine neoplasia syndrome type 2, per the FDA

Nutr Metab Cardiovasc Dis 32(4):770814 Davies MJ, Aroda VR, Collins BS, Gabbay RA, Green J, Maruthur NM, Rosas SE, Del Prato S, Mathieu C, Mingrone G, Rossing P, Tankova T, Tsapas A, Buse JB (2022) Management of hyperglycaemia in type 2 diabetes, 2022

Both medications reduce appetite through GLP-1 receptor activation

Including regular strength or resistance exercise during treatment helps protect muscle mass further Wegovy (semaglutide) acts on the GLP-1 receptor to support appetite suppression and weight management, and it is available at a more affordable price point

In committee Feb

Distinct disease risk profiles have been documented among Black and Hispanic populations, reflecting unique pathophysiological patterns [118, 119]