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New research reveals how GLP-1 receptor drugs, known for treating diabetes and obesity, also protect the brains vital neurovascular system, offering hope for tackling cognitive decline and neurodegenerative diseases like Alzheimer's
Conclusion Increasing evidence suggests that anti-diabetes medicine, GLP-1R agonists, have multiple neuroprotective mechanisms in AD models, such as anti-inflammation, anti-oxidative stress, reducing A aggregation/deposition and tau protein hyperphosphorylation, reducing neuronal apoptosis and neurotoxicity, increasing cell proliferation and neurogenesis, increasing synaptic plasticity, and other beneficial effects
E Clinical Medicine
A review of 427,555 individuals prescribed a GLP-1RA for diabetes had a 12% increased risk of a new chronic cough compared with 1.6 million individuals prescribed a different second-line diabetes agent
An alternative perspective posits that the gut harbors a substantial population of immune cells and neural networks, and EGCG has the potential to modulate signaling and functional disruptions in intestinal neuroimmune communication via the brain-gut axis (13, 209211)
Most people do not need a hard avoid list, but greasy fried foods, very spicy foods, high-sugar drinks, and oversized meals commonly worsen nausea or reflux
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