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Clinically significant improvements in hemoglobin A1c typically require 12-16 weeks at the maintenance dose of 7 mg or 14 mg daily

A 2024 review in Circulation summarized the skeletal-muscle data across multiple GLP-1 trials and concluded that the observed changes appear adaptive rather than pathological. In March 2026, Langer and colleagues published a direct test of the muscle question in Cell Reports Medicine, albeit in mice

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