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These may include: Nausea Vomiting Diarrhea Constipation Bloating Mild fatigue Symptoms are most common when starting therapy or increasing the dose
TDM was supported for this work by funding from the German Research Foundation (DFG TRR296, TRR152, SFB1123, and GRK 2816/1), the German Center for Diabetes Research (DZD e.V.) and the European Research Council ERC-CoG Trusted no.101044445
To account for potential pleiotropy, in each analysis, we used different analytic methods robust to pleiotropy, including Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO), a weighted median, and weighted mode
Chromatogram of L-Carnitine Derivative Calculation: The content of L-carnitine in the sample is calculated using a data processing system or according to the following formula (the blank value must be subtracted from the calculation result): Where: X the concentration of the analyte in the sample, in milligrams per kilogram (mg/kg)
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