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Importantly, these medications carry a boxed warning for risk of thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), and are contraindicated in patients with personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2

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Studies have consistently found that grip strength and muscle mass are among the strongest predictors of healthy aging and reduced mortality risk

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These effects reflect both central nervous system involvement and peripheral actions observed in controlled research settings