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In the context of constitutive HIF-2 stabilization 75 or a defective mitochondrial electron transport chain 76 , glutamine-derived -KG is reductively carboxylated through the consumption of NADPH by IDH2 to generate citrate
This results in elevated intracellular NAD+ levels, optimized mitochondrial function, and enhanced energy metabolism without affecting appetite or caloric intake
[Additional acetaminophen metabolism and toxicity references available in full bibliography] 73
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