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Lamport DJ, Breese E, Giao MS, Chandra S, Orchard F

This rapid change can trigger musculoskeletal symptoms even as metabolic health improves

Serious but less common adverse effects include pancreatitis, gallbladder disease, acute kidney injury (particularly in the setting of dehydration from gastrointestinal symptoms), and hypoglycemia when used in combination with insulin or sulfonylureas

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Mitochondrial iron-sulfur cluster dysfunction in neurodegenerative disease

A novel PDE4 inhibitor ZX21011 alleviates neuronal apoptosis by decreasing GSK3-mediated Drp1 Ser616 phosphorylation in cerebral ischemia reperfusion