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When You Should See a Specialist Or Stop Treatment If a clinician suspects a true allergic reaction, they may recommend stopping tirzepatide and referring to an allergist for testing, or initiating short-course corticosteroids or other targeted treatments

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Readers are encouraged to consult the primary publication (Rosenstock et al., The Lancet, 2023) and the ClinicalTrials.gov record for full participant numbers, confidence intervals, and protocol details

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In vivo dosing of liraglutide in animals, followed by gene expression analysis of the hypothalamus, documented an increase in CART, but not POMC, mRNA and the inhibition of increases in neuropeptide Y/agouti-related peptide

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