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On top of the role of NAD + as a direct substrate for the TCA and ETC, much of the influence of NAD + on mitochondrial homeostasis is through the NAD + -consuming enzymes sirtuins
Each patients report is unique as coverage varies from plan to plan and drug to drug
Second, we performed analyses accounting for competing risk from other cancer diagnoses or death, using the method proposed by Fine and Gray [25,26,27]
Switching requires medical supervision
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