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Mice were treated subcutaneously at the indicated doses with 5 l per g body weight of either Vehicle, Lani (CAS: 927961-18-0, MedChemExpress), semaglutide, GLP-1Lani, GLP-1Tesa, GLP-1GIP, GLP-1GIPTesa, GLP-1GIPLani, or co-administration of either GLP-1GIP plus Lani or GLP-1Lani plus acyl-GIP (Extended Data Fig
Fiber also triggers GLP-1 by slowing gastric emptying since it digests slower
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Moreover, research has emphasized that apoptosis, lysosomal dysfunction, and altered autophagy are associated with salivary gland insufficiency and autoimmunity in SS [278,279,280]
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Titration (slow dose increases) helps mitigate this
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