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for example, reduced kidney function can extend elimination to 7 to 10 weeks, and real-world data show that 20% of patients discontinue semaglutide due to gastrointestinal side effects, which can cause abrupt timing changes

10.1016/s0022-2275(20)31566-2 J

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Gallbladder disease In patients with established gallbladder disease, the relative risks and benefits of a cholecystectomy or preventive treatment with ursodeoxycholic acid before starting GLP-1 receptor agonist therapy should be thoroughly discussed

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Zhang S, Wang L, Kang Y, Wu J, Zhang Z