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Glucagon-like Peptide-1 receptor agonists activate rodent thyroid C-cells
When using dilute acetic acid (0.1% v/v) as a solvent, it can improve initial solubilization of certain peptide batches, but the solution pH should be adjusted to near-physiological range before administration to avoid tissue irritation at the injection site in animal models
While the peptide was generally well-tolerated, it failed to perform significantly better than a matching placebo
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