In the Lira Pump study, they decreased basal insulin by 10%, but increased bolus by 15% ( Our current practice is to consider a ~20% bolus insulin decrease and a ~10% basal insulin decrease before GLP-1RA initiation, although prior A1c, risk of hypoglycemia, potential risk of ketosis due to reduced insulin doses, as well as other patient-specific factors should guide the final insulin dose changes
Weeks 1-4 begin at 2.5mg weekly
(2010) Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor
GLP-1-Medikamente und dein Zyklus: Wie Medikamente zur Gewichtsabnahme deine hormonelle Gesundheit beeinflussen Fragen & Antworten mit Dr
de Ceglia M, Decara J, Gaetani S, de Fonseca FR (2021) Obesity as a Condition determined by Food Addiction: should Brain Endocannabinoid System alterations be the cause and its Modulation the Solution
Wegovy uses the same active ingredient as Ozempic that has been approved for weight loss in the UK