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HPG axis central effects: hypothalamus and pituitary Evidence on the potential neuroendocrine actions of GLP-1 on HPG axis was provided by an in vitro study in a rodent hypothalamic neuronal cell line (GT1-7) that reported a dose-dependent stimulating effect of GLP-1 on GnRH release, in association with a prompt increase in the plasma LH levels following the intracerebroventricular injection of GLP-1 in male rats [34]
doi: 10.1523/JNEUROSCI.0529-11.2011 36 MakinS
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Los resultados de los ensayos en cuanto a la obesidad son claros: el 96% de los que tomaron el frmaco redujeron al menos un 5% de peso, y 4 de cada 10 lograron ms de un 25%
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