Two studies investigated animal models of comorbid depression and epilepsy 159,161 : one showed that exendin-4 led to an increase in frequency of absence seizures as well as depressogenic and anxiogenic responses 159 , while the other saw a decrease of depression-like behavior for liraglutide irrespective of concurrent use of the antiepileptic levetiracetam 161
In laboratory experiments using rat pituitary cells, ipamorelin was found to be as effective as a similar compound, GHRP-6, in releasing GH
Kulinsky VI & Kolesnichenko LS
By using random-effects model, the network meta-analysis indicated that the risk profile of DPP-4i was same as placebo in all the outcomes (44)
Because it is compounded, the exact strengths and schedule vary by pharmacy and prescriber
What This Means for GLP-1 Users A probiotic might modestly support gut transit, based on the meta-analysis evidence, but the magnitude is modest, the strain-level evidence is heterogeneous, and there is no direct trial in GLP-1 users