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While the peptide was generally well-tolerated, it failed to perform significantly better than a matching placebo
The triple-agonist approach is the biggest advancement in obesity pharmacology since GLP-1 agonists first hit the market
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Nat Med (2022) 28:233343
GIP(1-42) and GIP(1-30)NH 2 displayed equipotent effects on these pathways excluding CREB phosphorylation where GIP(1-30)NH 2 was more potent than GIP(1-42) at the E354Q GIP receptor
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