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[6] Caution is advised in patients with advanced renal impairment or those receiving dialysis, given the renal clearance of carnitine and the risk of accumulation

Serum B12 typically rises within six to twelve weeks of consistent daily supplementation

Orphanet J Rare Dis 16 , 215 (2021)

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Researchers are studying this pathway for possible effects on fat tissue, NAD+, and metabolism, but human benefits are not established