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Contact your GP if cold sensitivity is severe or persistent, or if accompanied by extreme fatigue, hair loss, unexplained weight gain, breathlessness, or colour changes in hands and feet, as these may indicate thyroid dysfunction, anaemia, or circulatory problems requiring investigation
Content and images used with permission from the Journal of Drugs in Dermatology
These complexes are anchored by the 5 helix of G s , which fits to the cytoplasmic cavity formed by TMs 2, 3, 5, 6, 7 and intracellular loop 1 (ICL1)
At 2 mg per injection, it falls far below the therapeutic oral doses of 500-3000 mg daily that have been studied for various conditions
Mounjaro/Zepbound is injected under the skin (subcutaneously) of your stomach (abdomen), thigh, or upper arm
We take that as a sign that the drug is working at that dose and we wait until that effect wears off before increasing the dose
