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References:
None of that means B12 is useless
The speed of response depends on factors including the severity and duration of deficiency, the presence of neurological complications, and individual metabolic differences
The human efficacy record is mixed: the fragment cleared safety trials but missed its primary weight endpoint in its largest study, and development for obesity stopped in 2007
Brescoll, 2015)
However, at doses higher than 50 mg per day, some side effects such as skin flushing can occur
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