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In the Geniposide group, there were 285 upregulated genes and 99 downregulated genes in comparison with the Model group

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The study found that while participants lost an average of 14.9% of their body weight, approximately 40% of the mass lost was lean mass (Wilding et al., 2021)

Under this condition, HIF-1 becomes stabilized and subsequently translocates to the nucleus, where it binds to hypoxia-responsive elements within target genes, thereby promoting metabolic programming, notably the upregulation of anaerobic glycolysis (37,38)

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