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Unlike phosphodiesterase-5 (PDE5) inhibitors such as sildenafil or tadalafil, which directly enhance nitric oxide signaling in penile tissue, tirzepatide's primary targets are metabolic receptors in the pancreas, gastrointestinal tract, and brain
References Bremelanotide (PT-141) 1,2 Bremelanotide, a MCR agonist, non-selectively works on several receptor subtypes MC1R-MC5R in the central nervous system
Am J Physiol (1999) 277:G82937
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