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Mechanism of Action Dulaglutide and semaglutide are both GLP1 drugs synthesized and manufactured in the lab and thus work primarily the same.[6,8,10,11] Both of these medications mimic the GLP1 naturally produced in the human body

doi: 10.1177/15598276251344827 Retrieved from Nicolau, J., Blanco-Anesto, J., Bonet, A., et al

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Let's start with understanding why this combination works

Important scientific distinction Public sources support the individual chemical identities and the general mechanistic rationale for combining GHRH- and GHRP-class ligands

You might think clinical studies and patient guidelines dictate which drug you get, but there's a third major player: PBMs (Pharmacy Benefit Managers)