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Post-mortem brains and peripheral samples from BD patients have repeatedly shown altered mitochondrial genetics encoding for electron transport chain (ETC) complexes, oxidative stress imbalances, as well as increased levels of circulating cell free mitochondrial DNA (ccf-mtDNA) [7,8,9,10]
(7) Virmani MA, et al
Genome-wide probing of RNA structure reveals active unfolding of mRNA structures in vivo
Folic acid may actually reduce the Linea Negra, he shares
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This is a finding in our study that needs more verification as our sample was small
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