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Still, these positive results can be enhanced when in combination with other drugs, such as metformin, which allows for an effective treatment plan with no increase in adverse symptoms usually seen with the treatment of semaglutide alone [121, 122, 125, 126]
10.1002/dmrr.3173 Summary Keywords AMPK, anthracycline cardiotoxicity, autophagy, cardioprotection, diabetic cardiomyopathy, heart failure, ischemia-reperfusion injury, metformin Citation Khinchin J, Rakoubian A, Romano V, Ryan T, Yarbro J, Kobayashi S and Liang Q (2026) Repurposing metformin for cardioprotection: mechanisms and therapeutic potential across cardiovascular pathologies
O'Brien MD, Bruce BK, Camilleri M
Losing muscle can slow down your metabolism and make it harder to keep the weight off in the long term
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