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Because of the GI effects, caution is advised in patients with severe gastroparesis (e.g., long-standing diabetic gastroparesis) GLP-1 RAs can worsen gastric emptying delays and are generally not recommended in that scenario

Reconstitution with bacteriostatic water or an appropriate laboratory solvent is required prior to research use

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However, in many cases peripheral symptoms, such as muscle fatigue, either prevail or are an important part of the clinical presentation

consult a physician before use