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Ablation of the Mitochondrial Pyruvate Carrier alleviates ER stress Finally, we wished to test whether ER stress could be alleviated by non-pharmacological manipulation of TCA cycle activity

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4,5 Diabetic peripheral neuropathy (DPN), the most common form of DN, is characterized by distal symmetric polyneuropathy, leading to sensory loss, pain, and motor dysfunction in the extremities and is a primary cause of foot ulcers and lower-limb amputations in diabetes patients

To quantify cell death, slides were blinded and the first author (B.A.) counted the number of TUNELpositive cells in 10 highpower fields for each sample

Safety & Candidacy BPC/TB-15 high-dose therapy requires careful medical evaluation to ensure appropriate candidacy