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Some practitioners hold patients at 10 mg if weight loss trajectory is satisfactory, reserving higher doses for plateaus
A 30% variation in peak plasma level doesn't translate to a 30% variation in clinical outcome (oxidative stress markers, skin lightening, etc.)
The right choice depends on whether the injury is discrete and localized or diffuse and multi-site
Das T, Simone M, Ibugo AI, Witting PK, Manefield M, Manos J
Due to its water solubility, it has been estimated that only one molecule of morphine out of 1,000 molecules circulating in the blood actually gets into the brain to relieve pain and exert its array of pharmacologic activities
This places them at elevated risk for B12 deficiency, and standard oral supplementation may not provide adequate absorption
