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Lancet Diabetes Endocrinol 6:275286

The longitudinal relationship between hand, hip and knee osteoarthritis and cardiovascular events: a population-based cohort study

Semaglutide is delivered via a subcutaneous injection, meaning it is injected into the fatty tissue just beneath the skin

Monnier et al

Additional cardiovascular outcome trials showed semaglutide reduces the risk of major adverse events like heart attack and stroke

The key distinction is that adaptive muscle soreness improves over time, does not interfere significantly with daily activities, and is not accompanied by concerning symptoms like dark urine, severe weakness, or systemic signs like fever