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In this study we demonstrate that the fusion of human glutaredoxin-1 (Grx1) to roGFP2 facilitates specific real-time equilibration between the sensor protein and the glutathione redox couple

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Serious side effects like pancreatitis or thyroid cancer are rare

Among CagriSema-treated participants, 73.5% achieved HbA1c of 6.5% or below compared to 15.9% with placebo, demonstrating remarkable dual efficacy for both weight and glycemic endpoints

While 2.5 mg was not analyzed separately (it is an initiation dose in trials), it represents the lowest standard dose with established safety data