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Eshleman AJ, Wolfrum KM, Reed JF, Kim SO, Johnson RA, Janowsky A
Why the cheap, safe, evidence-backed option comes first
This might reflect an adaptation to favor the maintenance of NADPH pools, an essential co-factor in hundreds of biochemical reactions, at the expense of other critical pathways including energy production and nucleotide-activated sugar synthesis
The answer depends on what you are trying to fix
Ultimately, the central challenge for all cleavable linker technologies lies in balancing this potent efficacy against the risk of off-target toxicity from premature cleavage
If nausea becomes a problem, let your doctor know
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