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[3] Controlled evidence demonstrating clinically meaningful weight loss from these injections is lacking

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IEEE Sensors J

The Aib substitution (-aminoisobutyric acid) that distinguishes Ipamorelin from other GHRPs is the primary structural determinant of its selectivity reducing interactions with hypothalamic CRH neurons that drive cortisol co-stimulation in less selective GHRPs such as GHRP-2 and Hexarelin