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Pharmacological mechanism of Huanglian Jiedutang: a review
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Decreased NAD + levels can contribute to sirtuin mediated deacetylase-dependent alterations in both mitochondrial electron transport activity (resulting in increased production of reactive oxygen species, ROS) as well as to increased nuclear DNA damage leading to the activation poly-ADP-ribose polymerases (PARP)
But overall, the dominant pattern seems to be daily administration
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